AustralieFrV1, Main, Exploration, bibRecord, 002D67

Gait phenotype from MCI to moderate dementia: results from the GOOD initiative

Identifieur interne : 002D67 ( Main/Exploration ); précédent : 002D66; suivant : 002D68

Gait phenotype from MCI to moderate dementia: results from the GOOD initiative

Auteurs : Gilles Allali [États-Unis, Suisse] ; Cédric Annweiler [France, Canada] ; Helena M. Blumen [États-Unis] ; Michele L. Callisaya [Australie] ; Anne-Marie De Cock [Belgique] ; Reto W. Kressig [Suisse] ; Velandai Srikanth [Australie] ; Jean-Paul Steinmetz [Luxembourg (pays)] ; Joe Verghese [États-Unis] ; Olivier Beauchet [France, Canada]

Source :

European journal of neurology [ 1351-5101 ] ; 2015.

RBID : PMC:4769662

Descripteurs français

KwdFr :
- Amnésie (), Amnésie (physiopathologie), Dysfonctionnement cognitif (), Dysfonctionnement cognitif (physiopathologie), Démence (), Démence (physiopathologie), Femelle, Humains, Maladie d'Alzheimer (), Maladie d'Alzheimer (physiopathologie), Mâle, Phénotype, Sujet âgé, Sujet âgé de 80 ans ou plus, Troubles neurologiques de la marche (physiopathologie), Troubles neurologiques de la marche (étiologie), Études transversales.
MESH :
- physiopathologie : Amnésie, Dysfonctionnement cognitif, Démence, Maladie d'Alzheimer, Troubles neurologiques de la marche.
- étiologie : Troubles neurologiques de la marche.
- Amnésie, Dysfonctionnement cognitif, Démence, Femelle, Humains, Maladie d'Alzheimer, Mâle, Phénotype, Sujet âgé, Sujet âgé de 80 ans ou plus, Études transversales.

English descriptors

KwdEn :
- Aged, Aged, 80 and over, Alzheimer Disease (complications), Alzheimer Disease (physiopathology), Amnesia (complications), Amnesia (physiopathology), Cognitive Dysfunction (complications), Cognitive Dysfunction (physiopathology), Cross-Sectional Studies, Dementia (complications), Dementia (physiopathology), Female, Gait Disorders, Neurologic (etiology), Gait Disorders, Neurologic (physiopathology), Humans, Male, Phenotype.
MESH :
- complications : Alzheimer Disease, Amnesia, Cognitive Dysfunction, Dementia.
- etiology : Gait Disorders, Neurologic.
- physiopathology : Alzheimer Disease, Amnesia, Cognitive Dysfunction, Dementia, Gait Disorders, Neurologic.
- Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Male, Phenotype.

Abstract

Background

The differences in gait abnormalities from the earliest to the latter stages of dementia and in the different subtypes of dementia have not been fully examined. This study aims to compare spatio-temporal gait parameters in cognitively healthy individuals, patients with amnestic (aMCI) and non-amnestic (naMCI) MCI, and patients with mild and moderate stages of Alzheimer’s disease (AD) and non-Alzheimer’s disease (non-AD).

Methods

Based on a cross-sectional design, 1719 participants (77.4±7.3 years, 53.9% female) were recruited from cohorts from seven countries participating in the “Gait, cOgnitiOn & Decline” initiative. Mean values and coefficients of variation of spatio-temporal gait parameters were measured during normal pace walking with the GAITRite system at all sites.

Results

Performance of spatio-temporal gait parameters declined in parallel to the stage of cognitive decline from MCI status to moderate dementia. Gait parameters of patients with naMCI were more disturbed compared to patients with aMCI, and MCI subgroups performed better than demented patients. Patients with non-AD dementia had worse gait performance than those with AD dementia. This degradation of the gait parameters was similar between mean values and coefficients of variation of spatio-temporal gait parameters in the earliest stages of cognitive decline, but different in the most advanced stages, especially in the non-AD subtypes.

Conclusions

Spatio-temporal gait parameters were more disturbed in the advanced stages of dementia, and more affected in the non-AD dementias than in AD. These findings suggest that quantitative gait parameters could be used as a surrogate marker for improving the diagnosis of dementia.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4769662

DOI: 10.1111/ene.12882
PubMed: 26662508
PubMed Central: 4769662

Affiliations:

Le document en format XML

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</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A12">Department of Medicine, Division of Geriatric Medicine, Jewish General Hospital, McGill University, Montréal, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Medicine, Division of Geriatric Medicine, Jewish General Hospital, McGill University, Montréal</wicri:regionArea>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
<settlement type="city">Montréal</settlement>
</placeName>
<orgName type="university">Université McGill</orgName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A13">Biomathics, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Biomathics, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">European journal of neurology</title>
<idno type="ISSN">1351-5101</idno>
<idno type="eISSN">1468-1331</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Alzheimer Disease (complications)</term>
<term>Alzheimer Disease (physiopathology)</term>
<term>Amnesia (complications)</term>
<term>Amnesia (physiopathology)</term>
<term>Cognitive Dysfunction (complications)</term>
<term>Cognitive Dysfunction (physiopathology)</term>
<term>Cross-Sectional Studies</term>
<term>Dementia (complications)</term>
<term>Dementia (physiopathology)</term>
<term>Female</term>
<term>Gait Disorders, Neurologic (etiology)</term>
<term>Gait Disorders, Neurologic (physiopathology)</term>
<term>Humans</term>
<term>Male</term>
<term>Phenotype</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Amnésie ()</term>
<term>Amnésie (physiopathologie)</term>
<term>Dysfonctionnement cognitif ()</term>
<term>Dysfonctionnement cognitif (physiopathologie)</term>
<term>Démence ()</term>
<term>Démence (physiopathologie)</term>
<term>Femelle</term>
<term>Humains</term>
<term>Maladie d'Alzheimer ()</term>
<term>Maladie d'Alzheimer (physiopathologie)</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Troubles neurologiques de la marche (physiopathologie)</term>
<term>Troubles neurologiques de la marche (étiologie)</term>
<term>Études transversales</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Alzheimer Disease</term>
<term>Amnesia</term>
<term>Cognitive Dysfunction</term>
<term>Dementia</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Gait Disorders, Neurologic</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathologie" xml:lang="fr"><term>Amnésie</term>
<term>Dysfonctionnement cognitif</term>
<term>Démence</term>
<term>Maladie d'Alzheimer</term>
<term>Troubles neurologiques de la marche</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Alzheimer Disease</term>
<term>Amnesia</term>
<term>Cognitive Dysfunction</term>
<term>Dementia</term>
<term>Gait Disorders, Neurologic</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Troubles neurologiques de la marche</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Phenotype</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Amnésie</term>
<term>Dysfonctionnement cognitif</term>
<term>Démence</term>
<term>Femelle</term>
<term>Humains</term>
<term>Maladie d'Alzheimer</term>
<term>Mâle</term>
<term>Phénotype</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Études transversales</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title>
<p id="P1">The differences in gait abnormalities from the earliest to the latter stages of dementia and in the different subtypes of dementia have not been fully examined. This study aims to compare spatio-temporal gait parameters in cognitively healthy individuals, patients with amnestic (aMCI) and non-amnestic (naMCI) MCI, and patients with mild and moderate stages of Alzheimer’s disease (AD) and non-Alzheimer’s disease (non-AD).</p>
</sec>
<sec id="S2"><title>Methods</title>
<p id="P2">Based on a cross-sectional design, 1719 participants (77.4±7.3 years, 53.9% female) were recruited from cohorts from seven countries participating in the “Gait, cOgnitiOn & Decline” initiative. Mean values and coefficients of variation of spatio-temporal gait parameters were measured during normal pace walking with the GAITRite system at all sites.</p>
</sec>
<sec id="S3"><title>Results</title>
<p id="P3">Performance of spatio-temporal gait parameters declined in parallel to the stage of cognitive decline from MCI status to moderate dementia. Gait parameters of patients with naMCI were more disturbed compared to patients with aMCI, and MCI subgroups performed better than demented patients. Patients with non-AD dementia had worse gait performance than those with AD dementia. This degradation of the gait parameters was similar between mean values and coefficients of variation of spatio-temporal gait parameters in the earliest stages of cognitive decline, but different in the most advanced stages, especially in the non-AD subtypes.</p>
</sec>
<sec id="S4"><title>Conclusions</title>
<p id="P4">Spatio-temporal gait parameters were more disturbed in the advanced stages of dementia, and more affected in the non-AD dementias than in AD. These findings suggest that quantitative gait parameters could be used as a surrogate marker for improving the diagnosis of dementia.</p>
</sec>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Belgique</li>
<li>Canada</li>
<li>France</li>
<li>Luxembourg (pays)</li>
<li>Suisse</li>
<li>États-Unis</li>
</country>
<region><li>Pays de la Loire</li>
<li>Province d'Anvers</li>
<li>Québec</li>
<li>Région flamande</li>
<li>État de New York</li>
<li>Île-de-France</li>
</region>
<settlement><li>Angers</li>
<li>Anvers</li>
<li>Montréal</li>
<li>Paris</li>
</settlement>
<orgName><li>Université McGill</li>
<li>Université d'Anvers</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="État de New York"><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name>
</region>
<name sortKey="Blumen, Helena M" sort="Blumen, Helena M" uniqKey="Blumen H" first="Helena M." last="Blumen">Helena M. Blumen</name>
<name sortKey="Verghese, Joe" sort="Verghese, Joe" uniqKey="Verghese J" first="Joe" last="Verghese">Joe Verghese</name>
</country>
<country name="Suisse"><noRegion><name sortKey="Allali, Gilles" sort="Allali, Gilles" uniqKey="Allali G" first="Gilles" last="Allali">Gilles Allali</name>
</noRegion>
<name sortKey="Kressig, Reto W" sort="Kressig, Reto W" uniqKey="Kressig R" first="Reto W." last="Kressig">Reto W. Kressig</name>
</country>
<country name="France"><region name="Pays de la Loire"><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name>
</region>
<name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name>
<name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name>
</country>
<country name="Canada"><noRegion><name sortKey="Annweiler, Cedric" sort="Annweiler, Cedric" uniqKey="Annweiler C" first="Cédric" last="Annweiler">Cédric Annweiler</name>
</noRegion>
<name sortKey="Beauchet, Olivier" sort="Beauchet, Olivier" uniqKey="Beauchet O" first="Olivier" last="Beauchet">Olivier Beauchet</name>
</country>
<country name="Australie"><noRegion><name sortKey="Callisaya, Michele L" sort="Callisaya, Michele L" uniqKey="Callisaya M" first="Michele L." last="Callisaya">Michele L. Callisaya</name>
</noRegion>
<name sortKey="Callisaya, Michele L" sort="Callisaya, Michele L" uniqKey="Callisaya M" first="Michele L." last="Callisaya">Michele L. Callisaya</name>
<name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
</country>
<country name="Belgique"><noRegion><name sortKey="De Cock, Anne Marie" sort="De Cock, Anne Marie" uniqKey="De Cock A" first="Anne-Marie" last="De Cock">Anne-Marie De Cock</name>
</noRegion>
<name sortKey="De Cock, Anne Marie" sort="De Cock, Anne Marie" uniqKey="De Cock A" first="Anne-Marie" last="De Cock">Anne-Marie De Cock</name>
<name sortKey="De Cock, Anne Marie" sort="De Cock, Anne Marie" uniqKey="De Cock A" first="Anne-Marie" last="De Cock">Anne-Marie De Cock</name>
</country>
<country name="Luxembourg (pays)"><noRegion><name sortKey="Steinmetz, Jean Paul" sort="Steinmetz, Jean Paul" uniqKey="Steinmetz J" first="Jean-Paul" last="Steinmetz">Jean-Paul Steinmetz</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Gait phenotype from MCI to moderate dementia: results from the GOOD initiative

Gait phenotype from MCI to moderate dementia: results from the GOOD initiative

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